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The American Journal of Clinical Nutrition 77 (1): 18995

The earliest controlled human evidence for luteolins neuroimmune effects comes from a randomized, double-blind clinical trial that evaluated a complex of PEA-LUT in children with autism spectrum disorder ( A recent double-blind, placebo-controlled crossover trial evaluated the effects of luteolin supplementation (250 mg taken twice daily for 2 weeks) on neurocognitive performance in healthy adults

Furthermore, GDF15 (growth differentiation factor 15), a member of the TGFB superfamily produced by stressed cells, plays a role in reducing food intake by binding to its receptor GFRAL (GDNF family receptor alpha like) in the area postrema [208]